Online Oligo Synthesis Services

Oligonucleotides, often known as oligos, are short strands of synthetic DNA or RNA that the user has constructed. Synthesis is the method used to create custom oligos (or more specifically, solid-phase chemical synthesis). The nucleic acids Cytosine (C), Guanine (G), Adenine (A), Thymine (T) for DNA, and Uracil (U) for RNA are sequentially added to a developing chain of nucleotides in oligo synthesis. The nucleic acids must be constructed on their phosphate backbone to form the chain, which is then produced in the 3' to 5' orientation.


After synthesis, the oligo is usually desalted (all salts utilized during synthesis are removed) and/or purified (removes non-full-length material). In the polymerase chain reaction(PCR), oligos are routinely utilized. PCR is a technique for producing thousands or millions of copies of a single strand of DNA for use in other downstream applications (i.e. cloning, sequencing, etc.). Primers are oligos that are between 20 and 35 bases long and are utilized in PCR.


qPCR (quantitative PCR), gene editing and overexpression, site directed mutagenesis, fluorescence resonance energy transfer (FRET) assays, in situ hybridization (ISH), and single nucleotide polymorphism (SNP) assays are some of the other applications that use bespoke DNA oligos. Gene-targeted medicines also make use of oligos. All of these applications necessitate the creation of custom DNA (or RNA) oligos with user-specific sequences.


How to find online oligo synthesis services?


Bio Basic is a reliable online platform that offers oligo synthesis services at the most competitive prices. We offer purification types, modification list, price list(pricing and turnaround),etc. we have over 15 years of experience in synthesizing oligonucleotides for various types of research applications. Our production methods include- Desalted purification, high affinity purification, PAGE, HPLC and HPLC-CE Purification. We also specialize in modified oligonucleotides including Spacers, Linkers, Fluorophores, Quenchers, Phosphorylation, Modified Bases, Probes and many more.


We offer a fixed final yield for our oligo deliverables. You can also contact the team at Bio Basic to discuss your requirements.

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